PSPC1: a contextual determinant of tumor progression

Tumor Stiffening, a Key Determinant of Tumor Progression, is Reversed by Nanomaterial-Induced Photothermal Therapy

Tumor stiffening, stemming from aberrant production and organization of extracellular matrix (ECM), has been considered a predictive marker of tumor malignancy, non-invasively assessed by ultrasound shear wave elastography (SWE). Being more than a passive marker, tumor stiffening restricts the delivery of diagnostic and therapeutic agents to the tumor and per se could modulate cellular mechano-...

Role of the polarity determinant crumbs in suppressing mammalian epithelial tumor progression.

Most tumors are epithelial-derived, and although disruption of polarity and aberrant cellular junction formation is a poor prognosticator in human cancer, the role of polarity determinants in oncogenesis is poorly understood. Using in vivo selection, we identified a mammalian orthologue of the Drosophila polarity regulator crumbs as a gene whose loss of expression promotes tumor progression. Im...

Sex composition of children as a determinant of parity progression

Mammalian Epithelial Tumor Progression Role of the Polarity Determinant Crumbs in Suppressing

Most tumors are epithelial-derived, and although disruption of polarity and aberrant cellular junction formation is a poor prognosticator in human cancer, the role of polarity determinants in oncogenesis is poorly understood. Using in vivo selection, we identified a mammalian orthologue of the Drosophila polarity regulator crumbs as a gene whose loss of expression promotes tumor progression. Im...

HIV-1 subtype as a determinant of disease progression.

Although the average time from infection with HIV type 1 (HIV-1) to the development of AIDS is 1 decade, the rate of disease progression varies considerably among infected persons. Numerous factors, including plasma HIV-1 RNA level, CD4 cell count, degree of immune activation, age, socioeconomic status, and host genetics, contribute to determining the rate of progression in the individual patie...